Eficácia de metronidazol foi demonstrada nos seguintes estudos: 'Metronidazole - A therapeutic Review and Update.' (FREEMAN, C. D 1997); 'Prevention of postcesaren infectiouos morbidity with a single dose of intravenous metronidazole. (RUIZ-MORENO, J.A. 1991); 'Efficacy of intravaginal 0,75 metronidazole gel for the treatment of bacterial vaginosis.' (HILLER, S.H. 1993); 'Comparation of oral and vaginal metronidazole therapy for nospecific bacterial vaginosis. Gynecol.' (BISTOLETTI, P. 1986); 'Estudio multicêntrico nacional metronidazol-nistatin em infecciones vaginales mixtas (tricomona + Cândida).' (Somera, J. 1987).